Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327448 | 0.86 | NPC1 (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9690645 | 0.86 | TDP1 (0.50) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8326516 | 0.78 | MEN1 (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2420837 | 0.78 | KMT2A (0.40) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11035983 | 0.78 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23145042 | 0.77 | KMT2A (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL29843352 | 0.77 | KMT2A (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8324245 | 0.77 | TSHR (0.42) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1902321 | 0.76 | KDM4E (0.44) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8561203 | 0.75 | GAA (0.49) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |