Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669264 | 0.84 | NPC1 (0.44) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL14591311 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1B | |
| SCHEMBL30385365 | 0.81 | TRPV1 (0.56) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL8672558 | 0.81 | TRPV1 (0.56) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL30385657 | 0.81 | TRPV1 (0.56) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL4827684 | 0.78 | SLC18A3 (0.40) | NPC1RAB9ASLC18A3ALDH1A1MEN1 | |
| SCHEMBL8668624 | 0.78 | RXFP1 (0.40) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL30612403 | 0.75 | MTNR1A (0.53) | MTNR1AMTNR1BKMT2A | |
| SCHEMBL8672548 | 0.74 | SLC18A3 (0.52) | NPC1RAB9ASLC18A3MTNR1AMTNR1B | |
| SCHEMBL9186494 | 0.73 | DRD2 (0.55) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |