SCHEMBL8669264

SCHEMBL8669264

CC(=O)Nc1cccc2c1CC(OS(C)(=O)=O)CC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SLC18A3 Q16572 1/20 0.43
MTNR1A P48039 3/20 0.43
MTNR1B P49286 3/20 0.43
TRPV1 Q8NER1 9/20 0.40
ALDH1A1 P00352 1/20 0.40
ADRA2A P08913 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39
TUBB2A Q13885 1/20 0.39
TUBB8 Q3ZCM7 1/20 0.39
TUBA3E Q6PEY2 1/20 0.39
TUBA1A Q71U36 1/20 0.39
TUBA1C Q9BQE3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8670333 0.84 NPC1 (0.47) NPC1RAB9ASLC18A3MTNR1AMTNR1B
SCHEMBL8671532 0.81 MTNR1A (0.40) MTNR1AMTNR1B
SCHEMBL30385365 0.80 TRPV1 (0.56) NPC1RAB9ASLC18A3MTNR1AMTNR1B
SCHEMBL8672558 0.80 TRPV1 (0.56) NPC1RAB9ASLC18A3MTNR1AMTNR1B
SCHEMBL30385657 0.80 TRPV1 (0.56) NPC1RAB9ASLC18A3MTNR1AMTNR1B
SCHEMBL6953263 0.72 CA1 (0.45) MTNR1AMTNR1B
SCHEMBL4857120 0.72 CA1 (0.45) MTNR1AMTNR1B
SCHEMBL8672548 0.72 SLC18A3 (0.52) NPC1RAB9ASLC18A3MTNR1AMTNR1B
SCHEMBL9186494 0.71 DRD2 (0.55) MTNR1AMTNR1B
SCHEMBL5982154 0.70 CA2 (0.41) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5721234-A TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE WARNER-LAMBERT COMPANY (US) 1998-02-24 US disclosed
WO-1998005651-A1 NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES WARNER-LAMBERT COMPANY (US) 1998-02-12 WO disclosed
WO-1996017832-A1 NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES WARNER-LAMBERT COMPANY (US) 1996-06-13 WO disclosed