Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 3/20 | 0.41 |
| ▸ | PYGM | P11217 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187216 | 0.90 | L3MBTL1 (0.50) | LMNAPDGFRAKDRFAAHTDP1 | |
| SCHEMBL8173385 | 0.90 | PYGL (0.47) | LMNAPYGLPYGMPDGFRAKDR | |
| SCHEMBL8182917 | 0.88 | PYGL (0.46) | LMNACYP19A1PYGLPYGMPDGFRA | |
| SCHEMBL1387707 | 0.87 | P2RY1 (0.45) | LMNACYP19A1FAAHMEN1KMT2A | |
| SCHEMBL8187925 | 0.84 | PDGFRA (0.45) | LMNAPDGFRAKDRFAAHTDP1 | |
| SCHEMBL8670131 | 0.83 | TLR7 (0.38) | CYP19A1PYGLPYGMPDGFRAKDR | |
| SCHEMBL8183471 | 0.82 | MMP1 (0.39) | CYP19A1PYGLPYGMPDGFRAKDR | |
| SCHEMBL8674944 | 0.82 | PPARG (0.43) | CYP19A1PYGLPYGMPDGFRAKDR | |
| SCHEMBL9022907 | 0.82 | MMP1 (0.49) | LMNAKMT2AALDH1A1MAPK1KDM4E | |
| SCHEMBL8173788 | 0.82 | MEN1 (0.58) | LMNAPYGLPYGMFAAHTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776951-A | ANTICHOLESTEROL AGENT | GLAXO WELLCOME INC. (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0706508-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001326-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-12 | — | — | WO | disclosed |