Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181022 | 0.84 | MMP1 (0.49) | MMP1MMP13MMP2MMP9ALDH1A1 | |
| SCHEMBL8183471 | 0.84 | MMP1 (0.39) | MMP1MMP13MMP2MMP9ALDH1A1 | |
| SCHEMBL8189340 | 0.84 | FFAR1 (0.51) | KDM4E | |
| SCHEMBL8674075 | 0.83 | KMT2A (0.48) | ALDH1A1LMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL8173385 | 0.82 | PYGL (0.47) | ALDH1A1MAPK1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8187216 | 0.82 | L3MBTL1 (0.50) | ALDH1A1MAPK1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8670338 | 0.82 | LMNA (0.41) | ALDH1A1MAPK1LMNAKMT2AKDM4E | |
| SCHEMBL8187925 | 0.82 | PDGFRA (0.45) | ALDH1A1MAPK1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8182917 | 0.81 | PYGL (0.46) | ALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL8670131 | 0.81 | TLR7 (0.38) | MMP1MMP13MMP2MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706508-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001326-A1 | ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-12 | — | — | WO | disclosed |