Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990316 | 0.89 | IRAK4 (0.49) | MAPTIRAK4ALDH1A1 | |
| SCHEMBL8596165 | 0.87 | TP53 (0.45) | TP53PTGESHTT | |
| SCHEMBL8597312 | 0.84 | TP53 (0.43) | TP53PTGESHTT | |
| SCHEMBL8596516 | 0.83 | IRAK4 (0.49) | IRAK4KDM4E | |
| SCHEMBL8597937 | 0.82 | TP53 (0.43) | TP53PTGESHTT | |
| SCHEMBL8596981 | 0.81 | TP53 (0.44) | TP53PTGESALDH1A1HTT | |
| SCHEMBL8599109 | 0.81 | IRAK4 (0.49) | MAPTIRAK4 | |
| SCHEMBL8602447 | 0.81 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL8595161 | 0.81 | PTGES (0.42) | MAPTTP53PTGESALDH1A1KDM4E | |
| SCHEMBL8601161 | 0.81 | TP53 (0.46) | MAPTTP53PTGESALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |