Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.52 |
| ▸ | HEXB | P07686 | 6/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664254 | 0.87 | HEXA (0.69) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8666679 | 0.86 | HEXA (0.51) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8670400 | 0.85 | HEXA (0.53) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8671680 | 0.80 | HEXA (0.68) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8674616 | 0.80 | TERT (0.45) | HEXAHEXBKEAP1NFE2L2TLR9 | |
| SCHEMBL8395669 | 0.78 | SIRT1 (0.73) | HEXAHEXBCYP1B1OGASIRT1 | |
| SCHEMBL12673003 | 0.77 | HEXA (0.52) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8670304 | 0.76 | CYP2D6 (0.64) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL8668319 | 0.75 | HEXA (0.52) | HEXAHEXBCYP1B1OGAPOLB | |
| SCHEMBL6272260 | 0.72 | KEAP1 (0.65) | HEXAHEXBCYP1B1OGAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789418-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |