Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979783 | 0.80 | AGTR1 (0.48) | LTB4R2ACHEAGTR1AGTR2BDKRB1 | |
| SCHEMBL8979910 | 0.78 | BRS3 (0.46) | LTB4R2ACHEAGTR1AGTR2BDKRB1 | |
| SCHEMBL8801579 | 0.75 | AGTR1 (0.44) | LTB4R2ACHEAGTR1AGTR2BDKRB1 | |
| SCHEMBL8979781 | 0.75 | AGTR1 (0.48) | LTB4R2ACHEAGTR1AGTR2BDKRB1 | |
| SCHEMBL8979903 | 0.73 | BRS3 (0.47) | LTB4R2ACHEAGTR1AGTR2BDKRB1 | |
| SCHEMBL8672154 | 0.71 | ACHE (0.47) | ACHEAGTR1AGTR2BDKRB1BRS3 | |
| SCHEMBL8979760 | 0.70 | AGTR1 (0.49) | LTB4R2ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL8979880 | 0.70 | AGTR1 (0.49) | LTB4R2ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL8672211 | 0.70 | AGTR1 (0.49) | LTB4R2ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL8979750 | 0.69 | AGTR2 (0.55) | AGTR1AGTR2BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804583-A | Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA (IT) | 1998-09-08 | — | — | US | disclosed |