Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8118264 | 0.86 | DGAT2 (0.39) | KCNA5FFAR1CYP3A4KCNH2CYP17A1 | |
| SCHEMBL8552459 | 0.85 | CYP17A1 (0.44) | FFAR1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8109544 | 0.85 | SMN1; SMN2 (0.44) | KCNA5CYP3A4KCNH2GAACYP17A1 | |
| SCHEMBL8552624 | 0.85 | CYP19A1 (0.47) | KCNA5CYP3A4ALDH1A1CYP17A1CYP11B1 | |
| SCHEMBL8118689 | 0.84 | KCNA5 (0.48) | KCNA5CYP3A4NPY5RCYP17A1CYP11B1 | |
| SCHEMBL8123208 | 0.84 | MKNK1 (0.46) | FFAR1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8118468 | 0.84 | KCNA5 (0.45) | KCNA5FFAR1CYP3A4CYP3A5CYP17A1 | |
| SCHEMBL8552479 | 0.83 | PRKCI (0.44) | FFAR1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8117772 | 0.82 | KCNA5 (0.45) | KCNA5CYP3A4KCNH2ALDH1A1CYP17A1 | |
| SCHEMBL8555638 | 0.82 | SUCNR1 (0.43) | KCNA5FFAR1KCNH2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |