Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | G6PD | P11413 | 1/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 16/20 | 0.56 |
| ▸ | BCHE | P06276 | 11/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9029647 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Maleic Acid SCHEMBL8670810 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL9029655 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL9208733 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| SCHEMBL9536731 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL9208758 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Maleic Acid SCHEMBL8668041 | 0.82 | KDM4E (0.83) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL8883754 | 0.82 | KDM4E (0.83) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL9030046 | 0.82 | KDM4E (0.83) | KDM4EALDH1A1SMN1; SMN2LMNABLM | |
| Fumaric Acid SCHEMBL8882354 | 0.82 | ACHE (0.55) | KDM4EALDH1A1SMN1; SMN2LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726323-A | COMPOUNDS USEFUL FOR ALLEVIATING MEMORY DYSFUNCTIONS | HOECHST MARION ROUSSEL, INC. | 1998-03-10 | — | — | US | disclosed |