Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637106 | 0.77 | LTA4H (0.44) | LTA4HCCR8ALDH1A1MAPTHPGD | |
| SCHEMBL2356908 | 0.76 | SMN1; SMN2 (0.52) | LTA4HCCR8TSHRKMT2AALDH1A1 | |
| SCHEMBL7137486 | 0.74 | LTA4H (0.70) | LTA4HCCR8ALDH1A1NPSR1 | |
| SCHEMBL8637105 | 0.72 | NPSR1 (0.42) | LTA4HCCR8KMT2AMEN1ALDH1A1 | |
| SCHEMBL8773785 | 0.70 | LTA4H (0.44) | LTA4HS1PR1SMN1; SMN2 | |
| SCHEMBL16653897 | 0.69 | HTR2A (0.62) | KMT2AHTR2AMEN1 | |
| SCHEMBL8641935 | 0.67 | LTA4H (0.61) | LTA4HCCR8KMT2ASMN1; SMN2 | |
| SCHEMBL8551047 | 0.67 | MEN1 (0.59) | CCR8TSHRKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8554468 | 0.66 | MEN1 (0.58) | CCR8TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL3941089 | 0.64 | KDM4E (0.42) | LTA4HS1PR1TSHRHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |