Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19535305 | 0.82 | LTA4H (0.60) | LTA4HSLC18A3S1PR1S1PR5 | |
| SCHEMBL3635096 | 0.82 | LTA4H (0.60) | LTA4HSLC18A3S1PR1S1PR5 | |
| SCHEMBL8773749 | 0.74 | LTA4H (0.49) | LTA4HSLC18A3S1PR1S1PR5 | |
| SCHEMBL8637106 | 0.74 | LTA4H (0.44) | LTA4HABL1RIN1 | |
| SCHEMBL8773765 | 0.71 | LTA4H (0.70) | LTA4HNPC1RAB9ASMN1; SMN2S1PR1 | |
| SCHEMBL7137486 | 0.71 | LTA4H (0.70) | LTA4H | |
| SCHEMBL8675902 | 0.70 | LTA4H (0.45) | LTA4HSMN1; SMN2S1PR1 | |
| SCHEMBL8773741 | 0.70 | LTA4H (0.52) | LTA4HL3MBTL1S1PR1S1PR5 | |
| SCHEMBL24433074 | 0.65 | L3MBTL1 (0.51) | LTA4HNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1519223 | 0.65 | MEN1 (0.69) | LTA4HL3MBTL1S1PR1ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |