Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463651 | 0.84 | ALDH1A1 (0.46) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL7964491 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL1263805 | 0.78 | CA1 (0.54) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL7469324 | 0.78 | ALDH1A1 (0.51) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL7461497 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL7457655 | 0.76 | CA1 (0.51) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL11856166 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL12408515 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL7462938 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1POLBMAPTCA1 | |
| SCHEMBL9947508 | 0.74 | PLA2G2A (0.49) | KDM4EALDH1A1POLBMAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731344-A | DIABETES, ATHEROSCLEROSIS, ARTERIOSCLEROSIS; INHIBITORS OF ADVANCED GLYCOSYLATION ENDPRODUCTS | BOEHRINGER MANNHEIM GMBH (DE) | 1998-03-24 | — | — | US | disclosed |
| EP-0720608-B1 | NOVEL DIHISPIDINE DERIVATIVES, PROCESS FOR PRODUCING THEM AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-09 | — | — | EP | disclosed |
| WO-1995008547-A1 | NOVEL DIHISPIDINE DERIVATIVES, PROCESS FOR PRODUCING THEM AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1995-03-30 | — | — | WO | disclosed |