Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28457709 | 0.84 | EED (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL30466979 | 0.77 | MEN1 (0.67) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2185054 | 0.77 | MEN1 (0.67) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8676808 | 0.74 | NPC1 (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL21496659 | 0.73 | HDAC11 (0.62) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2647074 | 0.71 | CARM1 (0.42) | TRAP1ABHD6 | |
| SCHEMBL9966898 | 0.71 | ABHD6 (0.41) | TRAP1ABHD6TRPA1 | |
| SCHEMBL23505868 | 0.70 | TRAP1 (0.42) | TRAP1ABHD6TRPA1 | |
| SCHEMBL629986 | 0.70 | SIGMAR1 (0.46) | LMNA | |
| Hydrochloric Acid SCHEMBL2490663 | 0.69 | SIGMAR1 (0.44) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721248-A | CALCIUM AGONISTS; TREATING CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-24 | — | — | US | disclosed |
| US-5545646-A | CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-13 | — | — | US | disclosed |
| EP-0630895-A1 | 4-Bicyclic substituted dihydropyridines, process for their preparation and their use in medicaments | BAYER AG (DE) | 1994-12-28 | — | — | EP | disclosed |