Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13464088 | 0.82 | ABHD6 (0.47) | ABHD6CARM1PRMT6PRMT1AKR1C3 | |
| SCHEMBL2647074 | 0.75 | CARM1 (0.42) | ABHD6TRAP1CARM1PRMT6PRMT1 | |
| SCHEMBL8243999 | 0.75 | TIPARP (0.42) | TRAP1 | |
| SCHEMBL17887847 | 0.72 | ABHD6 (0.49) | ABHD6TRAP1CARM1PRMT6PRMT1 | |
| SCHEMBL5809499 | 0.71 | MAOA (0.44) | — | |
| SCHEMBL629986 | 0.71 | SIGMAR1 (0.46) | CARM1PRMT6PRMT1ACACB | |
| SCHEMBL23505868 | 0.71 | TRAP1 (0.42) | ABHD6TRAP1CARM1PRMT6PRMT1 | |
| SCHEMBL8677255 | 0.71 | MAPT (0.47) | ABHD6TRAP1TRPA1 | |
| Hydrochloric Acid SCHEMBL2490663 | 0.70 | SIGMAR1 (0.44) | CARM1PRMT6PRMT1ACACB | |
| SCHEMBL4437645 | 0.69 | ABHD6 (0.57) | ABHD6TRAP1CARM1PRMT6PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120818-B2 | Process and intermediates for preparing macrolactams | MERCK SHARP & DOHME CORP. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20130274463-A1 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS | MERCK SHARP & DOHME CORP. | 2013-10-17 | — | — | US | disclosed |
| WO-2012082672-A2 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS | MERCK SHARP & DOHME CORP. (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274463-A1 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS | EMG1, MRPS18B, MLN | ABHD6 964/4885TRAP1 3176/4885CARM1 4042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.