Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019265 | 0.96 | FAAH (0.55) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL10636400 | 0.84 | FAAH (0.58) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL22889048 | 0.81 | ALOX15 (0.43) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL12599419 | 0.81 | EPHX1 (0.59) | FAAHCNR1CNR2NAAAEPHX1 | |
| SCHEMBL10633033 | 0.80 | FAAH (0.57) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL10639411 | 0.80 | FAAH (0.57) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL11272584 | 0.80 | FAAH (0.57) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL11095613 | 0.80 | FAAH (0.57) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL26198744 | 0.79 | CHRNB2 (0.43) | FAAHCNR1CNR2NAAAKDM4E | |
| SCHEMBL28729643 | 0.78 | FAAH (0.73) | FAAHCNR1CNR2NAAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712268-A | Compositions of tricyclic β-lactams and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 1998-01-27 | — | — | US | disclosed |
| US-5698577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5510343-A | BETA-LACTAMASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1996-04-23 | — | — | US | disclosed |