SCHEMBL8679249

SCHEMBL8679249

CSC(=O)c1ccc(C)c(OC(F)F)c1C

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.31
ATM Q13315 1/20 0.30
GAA P10253 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2531130 0.82 ALDH1A1 (0.40) HTTRAB9A
SCHEMBL8680142 0.81 HTT (0.33) HTTRAB9AATMGAASMN1; SMN2
SCHEMBL6582254 0.80 SMN1; SMN2 (0.37) HTTRAB9ASMN1; SMN2
SCHEMBL8680145 0.76 ALDH1A1 (0.35) GAA
SCHEMBL13980116 0.73 MEN1 (0.33)
SCHEMBL8679253 0.73 ALDH1A1 (0.36) HTTGAA
SCHEMBL12433432 0.71 MEN1 (0.36) ATMGAASMN1; SMN2
SCHEMBL6584597 0.71 ALDH1A1 (0.38) RAB9AGAA
SCHEMBL25527063 0.69 MEN1 (0.33) GAASMN1; SMN2
SCHEMBL8488169 0.68 CES2 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5834404-A Substituted bicycloheptanedione derivative and herbicide NIPPON SODA CO., LTD. (JP) 1998-11-10 US disclosed
EP-0791572-A1 SUBSTITUTED BICYCLOHEPTANEDIONE DERIVATIVE AND HERBICIDE NIPPON SODA CO., LTD. (JP) 1997-08-27 EP disclosed