Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Bicine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | EYA2 | O00167 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicine SCHEMBL34161 | 0.90 | ALOX15 (0.68) | TDP1KDM4EALOX15BLMPMP22 | |
| Bicine SCHEMBL177696 | 0.90 | ALOX15 (0.68) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL526346 | 0.88 | BLM (0.54) | TDP1KDM4EALOX15BLMPMP22 | |
| Glycine SCHEMBL11442288 | 0.88 | GLRA1 (0.50) | TDP1KDM4EALOX15BLMPMP22 | |
| Glycine SCHEMBL11050532 | 0.88 | GLRA1 (0.50) | TDP1KDM4EALOX15BLMPMP22 | |
| Bicine SCHEMBL3981657 | 0.87 | ALOX15 (0.65) | TDP1KDM4EALOX15BLMPMP22 | |
| Trolamine SCHEMBL3090983 | 0.87 | GLRA1 (0.56) | TDP1KDM4EALOX15BLMPMP22 | |
| Bicine SCHEMBL1747701 | 0.87 | ALOX15 (0.65) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL8968107 | 0.87 | TDP1 (0.74) | TDP1KDM4EALOX15BLMPMP22 | |
| Bicine SCHEMBL5883443 | 0.87 | ALOX15 (0.65) | TDP1KDM4EALOX15BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108642070-B | Recombinant human Fc antibody for specifically inducing tumor cell apoptosis and preparation method and application thereof | 沈阳金石生物制药有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-113166794-A | Method for determining phosphoethanolamine, oxidoreductase for determining amount, composition for determining amount, kit for determining amount, and sensor for determining amount | 龟甲万株式会社 | 2021-07-23 | — | — | CN | disclosed |
| US-20120076784-A1 | HIGHLY CONCENTRATED, LIQUID FORMULATIONS OF ANTI-EGFR ANTIBODIES | MATHEUS SUSANNE (DE) | 2012-03-29 | — | — | US | disclosed |
| US-7960516-B2 | Solid forms of anti-EGFR antibodies | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |