Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | EYA2 | O00167 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL11050532 | 0.90 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2KDM4EALOX15 | |
| Glycine SCHEMBL11442288 | 0.90 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2KDM4EALOX15 | |
| Bicine SCHEMBL867955 | 0.87 | TDP1 (0.56) | GLRA1SLC6A9OR51E2KDM4EALOX15 | |
| Trolamine SCHEMBL1682239 | 0.82 | TDP1 (0.43) | GLRA1SLC6A9OR51E2KDM4EALOX15 | |
| Trolamine SCHEMBL11482407 | 0.82 | LMNA (0.44) | GLRA1SLC6A9OR51E2KDM4EALOX15 | |
| Trolamine SCHEMBL5874273 | 0.82 | ALOX15 (0.46) | OR51E2KDM4EALOX15MAPTSMN1; SMN2 | |
| Trolamine SCHEMBL28735231 | 0.82 | ALOX15 (0.46) | OR51E2KDM4EALOX15MAPTSMN1; SMN2 | |
| Trolamine SCHEMBL2587854 | 0.82 | ALOX15 (0.46) | OR51E2KDM4EALOX15MAPTSMN1; SMN2 | |
| Trolamine SCHEMBL10481892 | 0.80 | LDHA (0.53) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL1862550 | 0.80 | TDP1 (0.41) | OR51E2KDM4EALOX15MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250108339-A1 | ALKANOLAMINE-CONTAINING MEMBRANES AND METHODS OF MAKING AND USING THEREOF | UNITED STATES DEPARTMENT OFENERGY | 2025-04-03 | — | — | US | claimed |
| CN-118120770-A | Hydrogen peroxide disinfectant containing silver ions and production process thereof | 山东恒智医创医疗器械科技有限公司 | 2024-06-04 | — | — | CN | claimed |
| WO-2023141426-A1 | ALKANOLAMINE-CONTAINING MEMBRANES AND METHODS OF MAKING AND USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-27 | — | — | WO | claimed |
| CN-115487093-A | Shampoo without hair conditioner and preparation method thereof | 福建帮赞臣生物科技有限公司 | 2022-12-20 | — | — | CN | claimed |
| CN-112244040-B | Hydrogen peroxide silver ion composite disinfectant | 河南亿丰化学有限公司 | 2022-01-18 | — | — | CN | claimed |
| CN-112244040-A | Hydrogen peroxide silver ion composite disinfectant | 河南亿丰化学有限公司 | 2021-01-22 | — | — | CN | claimed |
| CN-108101235-A | A kind of method of biodegradation mineral oil in water | 中国人民解放军陆军勤务学院 | 2018-06-01 | — | — | CN | claimed |
| CN-105675749-B | The analysis method of cocoyl amino acid surfactant carbochain composition | 广州天赐高新材料股份有限公司 | 2017-07-18 | — | — | CN | claimed |
| CN-104193633-B | Modified calcium-base decarbonization, desulfuration agent preparation method and products thereof and application | 南京信息工程大学 | 2016-06-29 | — | — | CN | claimed |
| CN-105675749-A | Analysis method of carbon chain composition of cocoyl amino acid surfactants | 广州天赐高新材料股份有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-103046059-B | Environment-friendly concentrated multifunctional metal cleaning agent and preparation method thereof | XIAMEN KELONG FINE CHEMICAL CO LTD | 2015-05-06 | — | — | CN | claimed |
| CN-103046059-A | Environment-friendly concentrated multifunctional metal cleaning agent and preparation method thereof | XIAMEN KELONG FINE CHEMICAL CO LTD | 2013-04-17 | — | — | CN | claimed |
| US-20250108339-A1 | ALKANOLAMINE-CONTAINING MEMBRANES AND METHODS OF MAKING AND USING THEREOF | UNITED STATES DEPARTMENT OFENERGY | 2025-04-03 | — | — | US | disclosed |
| CN-118142464-B | Automatic production equipment of high-stability hydrogen peroxide disinfectant | 山东恒智医创医疗器械科技有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118142464-A | Automatic production equipment of high-stability hydrogen peroxide disinfectant | 山东恒智医创医疗器械科技有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-118120770-A | Hydrogen peroxide disinfectant containing silver ions and production process thereof | 山东恒智医创医疗器械科技有限公司 | 2024-06-04 | — | — | CN | disclosed |
| US-20080287536-A1 | Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes | BIODERM RESEARCH (US) | 2008-11-20 | — | — | US | disclosed |
| US-20060062751-A1 | Novel surfactants and use thereof | P & PF CO., LTD. (JP) | 2006-03-23 | — | — | US | disclosed |
| EP-1586625-A1 | NOVEL SURFACTANTS AND USE THEREOF | P & PF Co., Ltd. (JP) | 2005-10-19 | — | — | EP | disclosed |
| US-5179002-A | Dry reagent detector comprising carrier with aqueous indicator to determine carbon dioxide concentration; endotrachial catheter | NELLCOR INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287536-A1 | Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes | MMP17, MC1R, TYR | GLRA1 2460/4885SLC6A9 3574/4885OR51E2 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.