Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ACACA | Q13085 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10991494 | 0.94 | KDM4E (0.58) | MAPTTP53BACE1NPC1KMT2A | |
| SCHEMBL10976797 | 0.94 | KDM4E (0.58) | MAPTTP53BACE1NPC1KMT2A | |
| SCHEMBL8675465 | 0.94 | MAPT (0.59) | MAPTTP53NPC1MEN1KMT2A | |
| SCHEMBL8677193 | 0.87 | MAPT (0.52) | MAPTTP53NPC1MEN1KMT2A | |
| SCHEMBL8680333 | 0.85 | NPSR1 (0.54) | MAPTNPC1MEN1KMT2AKDM4E | |
| SCHEMBL8676667 | 0.84 | NPSR1 (0.55) | MAPTNPC1MEN1KMT2AKDM4E | |
| SCHEMBL10993183 | 0.81 | SQOR (0.53) | MAPTNPC1MEN1KMT2AKDM4E | |
| SCHEMBL10988161 | 0.81 | PIK3CA (0.50) | MAPTNPC1MEN1KMT2AKDM4E | |
| SCHEMBL10992874 | 0.81 | ACHE (0.49) | MAPTTP53NPC1MEN1KMT2A | |
| SCHEMBL5359428 | 0.81 | NPC1 (0.59) | MAPTNPC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750708-A | Pyridine compounds intermediates processes compositions and methods | ELI LILLY AND COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5672609-A | POSTMENOPAUSAL SYNDROME; ANTILIPEMIC AND -CARCINOGENIC AGENTS; OSTEOPOROSIS; CARDIOTONIC AGENTS; RESTENOSIS; SIDE EFFECT REDUCTION COMPARED TO ESTROGEN | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997004778-A1 | PYRIDINE COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-02-13 | — | — | WO | disclosed |