SCHEMBL8680603

SCHEMBL8680603

Cc1c(-c2ccccc2)ccc(C(C)(C)C)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41
ESR2 Q92731 1/20 0.38
PARP10 Q53GL7 1/20 0.38
PARP11 Q9NR21 1/20 0.38
CYP2A6 P11509 2/20 0.36
CYP2B6 P20813 1/20 0.36
ALDH1A1 P00352 3/20 0.35
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
AKT1 P31749 1/20 0.34
AKT2 P31751 1/20 0.34
BACE1 P56817 1/20 0.33
ALOX5 P09917 1/20 0.33
SQOR Q9Y6N5 1/20 0.33
VSIR Q9H7M9 1/20 0.33
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
ADORA2A P29274 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8679577 0.83 PDCD1 (0.50) PDCD1CD274ESR2PARP10PARP11
SCHEMBL9792869 0.82 PDCD1 (0.54) PDCD1CD274ESR2PARP10PARP11
SCHEMBL27843612 0.82 HSD11B1 (0.44) PDCD1CD274ESR2PARP10PARP11
SCHEMBL19287887 0.76 CA2 (0.41) ALDH1A1TSHRTDP1GABRA1GABRB2
SCHEMBL28506719 0.75 ALDH1A1 (0.35) ESR2CYP2A6CYP2B6ALDH1A1TSHR
SCHEMBL29092203 0.75 ALDH1A1 (0.50) ALDH1A1TSHRTDP1CNR1CNR2
SCHEMBL28026491 0.73 CA2 (0.50) ESR2ALDH1A1TSHRTDP1BACE1
SCHEMBL26193895 0.73 GABRA1 (0.44) CYP2A6ALDH1A1TSHRTDP1CNR1
SCHEMBL28762125 0.73 HSD11B1 (0.38) PDCD1CD274PARP10PARP11BACE1
SCHEMBL291792 0.73 ALDH1A1 (0.46) PDCD1CD274CYP2A6CYP2B6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817251-A AROMATIC HYDROCARBON LUBRICANT NIPPON OIL CO., LTD. (JP) 1998-10-06 US disclosed
US-5711895-A Fluid composition for use in a refrigerating machine in which the refrigerating machine oil is at least one hydrocarbon compound of a formula consisting of two phenyl groups joined through an alkylene or alkenylene group NIPPON OIL CO., LTD. (JP) 1998-01-27 US disclosed
EP-0717098-A2 A refrigerating machine oil and a fluid composition for use in a refrigerating machine NIPPON OIL CO. LTD. (JP) 1996-06-19 EP disclosed