Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682283 | 0.90 | KDM4E (0.40) | F2POLBMAPK1OPRM1 | |
| SCHEMBL8682542 | 0.75 | TTK (0.35) | POLBMAPK1HAO1MAP2K4MAPKAPK3 | |
| SCHEMBL8486574 | 0.75 | POLB (0.48) | POLBOPRM1CYP2D6 | |
| SCHEMBL6753577 | 0.74 | MAP2K4 (0.43) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL20025128 | 0.73 | POLB (0.47) | F2POLBOPRM1 | |
| SCHEMBL2042846 | 0.72 | POLB (0.47) | POLBOPRM1CYP2D6 | |
| SCHEMBL6958265 | 0.72 | POLB (0.44) | F2POLBOPRM1 | |
| SCHEMBL4955661 | 0.72 | ITGB3 (0.40) | POLBHTR1ADRD4OPRM1 | |
| SCHEMBL6566582 | 0.72 | POLB (0.47) | POLBOPRM1CYP3A4 | |
| SCHEMBL6302650 | 0.71 | POLB (0.43) | POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |