Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682545 | 0.90 | F2 (0.37) | POLBMAPK1OPRM1F2 | |
| SCHEMBL16607506 | 0.81 | NPC1 (0.41) | KDM4EALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL8682282 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1HCRTR1MEN1RAB9A | |
| SCHEMBL8684069 | 0.76 | RAB9A (0.46) | KDM4EALDH1A1HCRTR1MEN1RAB9A | |
| SCHEMBL26574069 | 0.75 | SMN1; SMN2 (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL9485102 | 0.73 | HCRTR1 (0.44) | KDM4EALDH1A1HCRTR1MEN1RAB9A | |
| SCHEMBL9485199 | 0.73 | HCRTR1 (0.50) | KDM4EALDH1A1HCRTR1MEN1RAB9A | |
| SCHEMBL6302650 | 0.71 | POLB (0.43) | MEN1KMT2ASMN1; SMN2POLBOPRM1 | |
| SCHEMBL8486574 | 0.71 | POLB (0.48) | MEN1KMT2ASMN1; SMN2POLBOPRM1 | |
| SCHEMBL9485928 | 0.71 | HCRTR1 (0.52) | KDM4EALDH1A1HCRTR1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |