Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144988 | 0.82 | KDM4E (0.50) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL1144846 | 0.79 | MAP2K4 (0.50) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL9485199 | 0.77 | HCRTR1 (0.50) | MAPK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15172582 | 0.76 | MAP2K4 (0.47) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL17514161 | 0.76 | MAP2K4 (0.47) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL31504557 | 0.74 | MAP2K4 (0.57) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL1145076 | 0.74 | MAP2K4 (0.57) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL8682545 | 0.74 | F2 (0.37) | MAP2K4MAPK1MAPKAPK3MAPK6MAPK3 | |
| SCHEMBL5989507 | 0.72 | HTR2C (0.58) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL8682718 | 0.72 | MAPK1 (0.44) | MAP2K4MAPK1MAPKAPK3MAPK6MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6759428-B2 | SUCH AS N-((1,2)-2-(((CYANO(CYCLOPROPYL)METHYL)AMINO)CARBONYL) CYCLOHEXYL)-1H-INDOLE-2-CARBOXAMIDE; CATHEPSIN K INHIBITORS | ROCHE PALO ALTO LLC | 2004-07-06 | — | — | US | disclosed |
| US-20040077646-A1 | Indole nitriles | ROCHE PALO ALTO LLC | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077646-A1 | Indole nitriles | TPH1, IDO1, NAT1 | MAP2K4 3007/4885MAPK1 903/4885MAPKAPK3 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.