Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658111 | 0.86 | KDM4E (0.37) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL27272748 | 0.84 | SLC22A12 (0.44) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL28472884 | 0.83 | TLR8 (0.41) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL7658563 | 0.82 | ALDH1A1 (0.43) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL28468125 | 0.81 | LOXL2 (0.46) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL7656202 | 0.81 | KDM4E (0.38) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL7655673 | 0.78 | LMNA (0.47) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL27541375 | 0.76 | SLC22A12 (0.47) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL23559707 | 0.74 | ADORA2A (0.47) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL28019314 | 0.74 | GRM4 (0.44) | KDM4EKMT2AALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |