SCHEMBL8683258

SCHEMBL8683258

Cc1cc(C(=O)C2CC2)ccn1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PROKR1 Q8TCW9 2/20 0.47
HTR1F P30939 1/20 0.44
ABL1 P00519 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
CYP2D6 P10635 1/20 0.44
GRM1 Q13255 3/20 0.42
PIK3C3 Q8NEB9 1/20 0.41
UHRF1 Q96T88 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
MAPT P10636 2/20 0.39
GSK3B P49841 2/20 0.39
JAK1 P23458 1/20 0.39
SLC6A3 Q01959 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25474402 0.80 UHRF1 (0.42) PROKR1ABL1UHRF1MAPTGSK3B
SCHEMBL12788104 0.79 TAS1R3 (0.50) PROKR1HTR1FGRM1PIK3C3HTR2A
SCHEMBL30533369 0.78 PROKR1 (0.50) PROKR1HTR1FMEN1KMT2ACYP2D6
SCHEMBL16319004 0.78 PROKR1 (0.50) PROKR1HTR1FMEN1KMT2ACYP2D6
SCHEMBL3356107 0.77 UHRF1 (0.50) PROKR1MEN1KMT2AUHRF1NPC1
SCHEMBL13736807 0.76 MYC (0.48) HTR1FGRM1PIK3C3NPC1RAB9A
SCHEMBL20446580 0.76 PROKR1 (0.40) PROKR1ABL1UHRF1MAPTGSK3B
SCHEMBL29527921 0.75 KDM4C (0.61) UHRF1MAPT
SCHEMBL29580893 0.75 UHRF1 (0.48) PROKR1MEN1KMT2AUHRF1NPC1
SCHEMBL353289 0.75 KDM4C (0.61) UHRF1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-10-31 US disclosed
US-11958849-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-16 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-10766892-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-09-08 US disclosed
US-10766892-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-09-08 US disclosed
US-20170291895-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2017-10-12 US disclosed
EP-3164394-A2 GLS1 INHIBITORS FOR TREATING DISEASE Board of Regents, The University of Texas System (US) 2017-05-10 EP disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
US-5821255-A REGULATING THE SECRETION OF CORTICOTROPIN, BETA-ENDORPHIN OR PEPTIDES DERIVED FROM PROOPIOMELANOCORTIN SANOFI (FR) 1998-10-13 US disclosed
US-5602132-A USEFUL IN TREATMENT OF PATHOLOGIES INVOLVING CORTICOTROPIN RELEASING FACTOR SANOFI (FR) 1997-02-11 US disclosed
US-5464847-A Moduators of corticotropin releasing factor ELF SANOFI (FR) 1995-11-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-10766892-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-11370786-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLB1 PROKR1 2332/4885HTR1F 3084/4885ABL1 3429/4885
US-11958849-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885
US-20170291895-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 PROKR1 3227/4885HTR1F 2669/4885ABL1 3617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.