Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31668328 | 1.00 | L3MBTL1 (0.55) | L3MBTL1TSHRRAB9APDCD1CD274 | |
| SCHEMBL14519052 | 0.81 | PTGS2 (0.64) | L3MBTL1ALDH1A1KDM4ETHRBKMT2A | |
| SCHEMBL9854713 | 0.80 | NOTUM (0.61) | RAB9AALDH1A1KMT2APOLBNOTUM | |
| SCHEMBL8686727 | 0.78 | APP (0.40) | PDCD1CD274ALDH1A1KMT2AHDAC8 | |
| SCHEMBL28721669 | 0.78 | L3MBTL1 (0.58) | L3MBTL1TSHRRAB9APDCD1CD274 | |
| SCHEMBL1247821 | 0.78 | TSHR (0.54) | L3MBTL1TSHRRAB9APDCD1CD274 | |
| SCHEMBL20905239 | 0.77 | NOTUM (0.40) | ALDH1A1ACHENOTUMIMPDH2 | |
| SCHEMBL10267835 | 0.76 | TSHR (0.55) | L3MBTL1TSHRRAB9APDCD1CD274 | |
| SCHEMBL28720956 | 0.76 | L3MBTL1 (0.55) | L3MBTL1TSHRRAB9APDCD1CD274 | |
| SCHEMBL8685214 | 0.75 | KMT2A (0.51) | RAB9AALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |