Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | LTC4S | Q16873 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28674705 | 0.84 | TSHR (0.49) | GRIK1LTC4SCHKAALDH1A1TP53 | |
| SCHEMBL28293629 | 0.81 | CHKA (0.45) | GRM5CYP11B2CHKAPYGLKCNMA1 | |
| SCHEMBL20838830 | 0.76 | GRM5 (0.40) | GRM5ALDH1A1TSHRUSP2KDM4C | |
| SCHEMBL10812471 | 0.76 | CYP3A4 (0.44) | GRM5ALDH1A1TSHRSMN1; SMN2MAPK1 | |
| SCHEMBL913751 | 0.75 | MKNK1 (0.44) | GRM5 | |
| SCHEMBL6643737 | 0.73 | SMN1; SMN2 (0.57) | GRIK1ALDH1A1TP53TSHRCASP1 | |
| SCHEMBL10814850 | 0.73 | HSP90AA1 (0.48) | GRM5ALDH1A1MEN1KMT2AKDM4C | |
| SCHEMBL12983823 | 0.73 | SYK (0.44) | GRM5ALDH1A1SMN1; SMN2KDM4C | |
| SCHEMBL11105220 | 0.73 | ALDH1A1 (0.49) | LTC4SCHKAALDH1A1TP53TSHR | |
| SCHEMBL29110277 | 0.72 | CYP11B2 (0.43) | GRIK1GRM5CYP11B2PYGLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783698-A | REACTING HALOFORMATE FUNCTIONALIZED POLYSTYRENE WITH SUBSTITUTED ANTHRANILIC ACID DERIVATIVE TO FORM URETHANE LINKAGE, REACTING THE INTERMEDIATE WITH PRIMARY AMINE TO FORM ANTHRANILAMIDES, HEATING, CYCLIZATION, LIBERATING END PRODUCT | MERCK SHARP & DOHME LIMITED (GB) | 1998-07-21 | — | — | US | disclosed |