Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 12/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686431 | 1.00 | APP (0.35) | APPBACE1BACE2HSD11B1MAPT | |
| SCHEMBL15974332 | 0.87 | GAA (0.36) | APPBACE1BACE2HSD11B1GAA | |
| SCHEMBL8958230 | 0.87 | GAA (0.36) | APPBACE1BACE2HSD11B1GAA | |
| SCHEMBL15974011 | 0.85 | GAA (0.36) | GAAMMP13RAB9ASMN1; SMN2 | |
| SCHEMBL542745 | 0.80 | TDP1 (0.36) | GAAMMP13RAB9ASMN1; SMN2 | |
| SCHEMBL542184 | 0.74 | ADAMTS7 (0.35) | — | |
| SCHEMBL7016401 | 0.73 | HSD11B1 (0.38) | APPBACE1BACE2HSD11B1MAPT | |
| SCHEMBL15974753 | 0.73 | APP (0.38) | APPBACE1BACE2HSD11B1 | |
| SCHEMBL15974080 | 0.72 | ALDH1A1 (0.42) | APPBACE1BACE2KMT2AALDH1A1 | |
| SCHEMBL11491694 | 0.71 | APP (0.34) | APPBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719296-A | THERAPY, PREVENTION OF AUTOIMMUNE DISEASES; PREVENTS PEPTIDE BINDING TO MAJOR HISTOCOMPATBILITY COMPLEX PROTEINS | MERCK & CO., INC. (US) | 1998-02-17 | — | — | US | claimed |