Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720601 | 0.84 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2GAAALDH1A1CYP3A4 | |
| SCHEMBL8792718 | 0.80 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2GAAALDH1A1RAPGEF4 | |
| SCHEMBL10561227 | 0.78 | GAA (0.58) | GAAALDH1A1CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL10976561 | 0.73 | GAA (0.56) | LMNASMN1; SMN2GAAALDH1A1CYP3A4 | |
| SCHEMBL1067726 | 0.71 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2GAAALDH1A1KDM4E | |
| SCHEMBL8561100 | 0.71 | LMNA (0.61) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL8793841 | 0.70 | LMNA (0.47) | LMNASMN1; SMN2GAAALDH1A1RAPGEF4 | |
| SCHEMBL15908246 | 0.70 | PKM (0.83) | SMN1; SMN2GAAALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL825670 | 0.70 | PKM (0.83) | SMN1; SMN2GAAALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL13665511 | 0.70 | PKM (0.83) | SMN1; SMN2GAAALDH1A1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840892-A | Process for the preparation of substituted pyrimidines | LONZA AG (CH) | 1998-11-24 | — | — | US | disclosed |
| EP-0802193-A1 | Process for the preparation of substituted pyrimidines | LONZA AG (CH) | 1997-10-22 | — | — | EP | disclosed |