Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26104648 | 0.72 | PDE9A (0.47) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL18320548 | 0.71 | USP2 (0.48) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL8123253 | 0.70 | USP2 (0.67) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL14969112 | 0.66 | ALOX15 (0.44) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL8525719 | 0.66 | PTK2 (0.65) | LMNASMN1; SMN2ALOX15MAPTALDH1A1 | |
| SCHEMBL26104687 | 0.65 | POLB (0.72) | LMNAUSP2KDM4EPOLBALOX15 | |
| SCHEMBL21963156 | 0.63 | ALOX15 (0.91) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL1062502 | 0.63 | LMNA (1.00) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL8114138 | 0.62 | USP2 (0.94) | LMNAPKMUSP2KDM4EPOLB | |
| SCHEMBL7434293 | 0.62 | KDM4E (0.71) | LMNAKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821248-A | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1998-10-13 | — | — | US | disclosed |
| US-5698568-A | Quinuclidine derivatives | PFIZER INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5641786-A | Quinuclidine derivatives | LOWE III JOHN ADAMS (US) | 1997-06-24 | — | — | US | disclosed |
| US-5422354-A | Quinuclidine derivatives | PFIZER INC (US) | 1995-06-06 | — | — | US | disclosed |
| WO-1992001688-A1 | QUINUCLIDINE DERIVATIVES | PFIZER INC. (US) | 1992-02-06 | — | — | WO | disclosed |