Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689118 | 0.87 | PTGS1 (0.49) | ALDH1A1KDM4EMEN1KMT2AHSD11B1 | |
| SCHEMBL8689434 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8689251 | 0.85 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDTDP1MEN1 | |
| SCHEMBL8691849 | 0.80 | PTGS2 (0.49) | ALDH1A1KDM4EHPGDHSD17B10CA2 | |
| SCHEMBL8688508 | 0.74 | PTGS1 (0.49) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL8688576 | 0.74 | PTGS1 (0.49) | ALDH1A1HPGDHSD17B10CA2CA1 | |
| SCHEMBL6512919 | 0.74 | CA12 (0.39) | ALDH1A1KDM4EMEN1KMT2ACA12 | |
| SCHEMBL8639252 | 0.74 | LMNA (0.48) | ALDH1A1KDM4EMEN1KMT2AHSD11B1 | |
| SCHEMBL8691625 | 0.72 | LMNA (0.53) | ALDH1A1KDM4EHSD11B1POLBGAA | |
| SCHEMBL8693263 | 0.72 | NPSR1 (0.46) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |