Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688508 | 0.91 | PTGS1 (0.49) | NPSR1LMNAMEN1KMT2APTGS1 | |
| SCHEMBL8639252 | 0.90 | LMNA (0.48) | NPSR1LMNAMEN1KMT2APTGS1 | |
| SCHEMBL8689251 | 0.87 | ALDH1A1 (0.42) | NPSR1LMNAMEN1KMT2APTGS1 | |
| SCHEMBL8637334 | 0.85 | NR3C1 (0.45) | NPSR1LMNAMEN1KMT2AKDM4E | |
| Benzenesulfonamide SCHEMBL8157094 | 0.85 | PTGS2 (0.60) | PTGS1PTGS2 | |
| SCHEMBL8692197 | 0.84 | HTT (0.50) | NPSR1LMNAMEN1KMT2ATSHR | |
| SCHEMBL8638994 | 0.82 | LMNA (0.46) | NPSR1LMNAMEN1KMT2APTGS1 | |
| SCHEMBL8688904 | 0.80 | ACLY (0.40) | MEN1KMT2APTGS1PTGS2KDM4E | |
| SCHEMBL8688576 | 0.80 | PTGS1 (0.49) | NPSR1LMNAPTGS1PTGS2ALDH1A1 | |
| SCHEMBL8693823 | 0.79 | PTGS2 (0.41) | MEN1KMT2APTGS1PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |