Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.40 |
| ▸ | ACLY | P53396 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688800 | 0.94 | PTGS2 (0.58) | PTGS2RXRANR1H2NR1H3PTGS1 | |
| SCHEMBL8637137 | 0.89 | RXRA (0.43) | PTGS2RXRANR1H2NR1H3PTGS1 | |
| SCHEMBL8689085 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1MAPT | |
| SCHEMBL8640692 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1MAPT | |
| SCHEMBL8689324 | 0.88 | PTGS2 (0.45) | PTGS2RXRANR1H2NR1H3PTGS1 | |
| SCHEMBL8637575 | 0.84 | PTGS2 (0.52) | PTGS2RXRANR1H2NR1H3PTGS1 | |
| SCHEMBL8694036 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1ACLY | |
| SCHEMBL8692172 | 0.84 | RXRA (0.44) | PTGS2RXRANR1H2NR1H3PTGS1 | |
| SCHEMBL7868758 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1MAPT | |
| SCHEMBL8640765 | 0.83 | PTGS1 (0.51) | PTGS2RXRANR1H2NR1H3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |