SCHEMBL8690728

SCHEMBL8690728

CC(C)(C)CC(=O)OOC1CCN(C(=O)CN)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CPN1 P15169 1/20 0.38
CPB2 Q96IY4 1/20 0.38
AOC2 O75106 1/20 0.37
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
DPP4 P27487 2/20 0.32
KCNQ3 O43525 2/20 0.32
KCNQ2 O43526 2/20 0.32
KCNQ4 P56696 1/20 0.32
KCNQ5 Q9NR82 1/20 0.32
ROCK2 O75116 1/20 0.32
ROCK1 Q13464 1/20 0.32
NPC1 O15118 1/20 0.32
FAAH O00519 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8690144 0.81 ROCK2 (0.35) DPP4KCNQ3KCNQ2ROCK2
SCHEMBL8379153 0.81 ROCK2 (0.35) DPP4KCNQ3KCNQ2ROCK2
SCHEMBL8882608 0.79 DPP4 (0.36) DPP4KCNQ3KCNQ2
SCHEMBL8716139 0.75 SMYD3 (0.34) KDM4E
SCHEMBL12890994 0.73 CYP2D6 (0.49) CPN1CPB2ALDH1A1LMNADPP4
SCHEMBL12801147 0.73 CPN1 (0.46) CPN1CPB2ALDH1A1KDM4ELMNA
SCHEMBL14820156 0.70 ALDH1A1 (0.50) AOC2ALDH1A1KDM4ELMNAMAPT
SCHEMBL20900695 0.70 CPN1 (0.47) CPN1CPB2ALDH1A1MAPTNPC1
SCHEMBL17320541 0.70 CPN1 (0.46) CPN1CPB2ALDH1A1DPP4NPC1
SCHEMBL12448251 0.69 CPN1 (0.50) CPN1CPB2ALDH1A1DPP4KCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5747522-A ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS HOFFMAN-LA ROCHE INC. (US) 1998-05-05 US disclosed
US-5670515-A TREATMENT OF THROMBOSIS, STROKE, CARDIAC INFARCT, INFLAMMATION, AND ARTERIOSCLEROSIS; ANTITUMOR AGENTS, WOUND HEALING AGENTS HOFFMANN-LA ROCHE INC. (US) 1997-09-23 US disclosed
US-5658928-A ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS HOFFMANN-LA ROCHE INC. (US) 1997-08-19 US disclosed
US-5545658-A FOR TREATMENT OR PROPHYLAXIS OF ILLNESSES WHICH ARE CAUSED BY THE BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELETS AND BY BLOOD PLATELET AGGREGATION AND CELL-CELL ADHESION HOFFMAN-LA ROCHE INC. (US) 1996-08-13 US disclosed
US-5378712-A Antithrombosis Hoffmann-La Roche Inc (US) 1995-01-03 US disclosed