SCHEMBL8690144

SCHEMBL8690144

C[C@@H](N)C(=O)N1CCC(OOC(=O)CC(C)(C)C)CC1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.35
SMYD3 Q9H7B4 14/20 0.35
HRH2 P25021 2/20 0.34
HRH1 P35367 2/20 0.34
HRH3 Q9Y5N1 1/20 0.34
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
DPP4 P27487 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8379153 1.00 ROCK2 (0.35) ROCK2SMYD3HRH2HRH1HRH3
SCHEMBL8882608 0.90 DPP4 (0.36) KCNQ3KCNQ2DPP4
SCHEMBL8690728 0.81 CPN1 (0.38) ROCK2KCNQ3KCNQ2DPP4
SCHEMBL8690804 0.80 SMYD3 (0.38) ROCK2SMYD3HRH2HRH1DPP4
SCHEMBL8383078 0.78 OPRD1 (0.49) SMYD3HRH2HRH1DPP4
SCHEMBL8716139 0.73 SMYD3 (0.34) SMYD3
SCHEMBL8379156 0.73 ITGB3 (0.42) SMYD3HRH2HRH1HRH3DPP4
SCHEMBL15045201 0.73 DPP4 (0.49) ROCK2SMYD3HRH3DPP4
SCHEMBL8690808 0.70 MEN1 (0.40) ROCK2SMYD3DPP4
SCHEMBL6435636 0.70 ITGB3 (0.55) SMYD3HRH2HRH1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5747522-A ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS HOFFMAN-LA ROCHE INC. (US) 1998-05-05 US disclosed
US-5670515-A TREATMENT OF THROMBOSIS, STROKE, CARDIAC INFARCT, INFLAMMATION, AND ARTERIOSCLEROSIS; ANTITUMOR AGENTS, WOUND HEALING AGENTS HOFFMANN-LA ROCHE INC. (US) 1997-09-23 US disclosed
US-5658928-A ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS HOFFMANN-LA ROCHE INC. (US) 1997-08-19 US disclosed
US-5545658-A FOR TREATMENT OR PROPHYLAXIS OF ILLNESSES WHICH ARE CAUSED BY THE BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELETS AND BY BLOOD PLATELET AGGREGATION AND CELL-CELL ADHESION HOFFMAN-LA ROCHE INC. (US) 1996-08-13 US disclosed