Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 6/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689215 | 0.91 | PTGS2 (0.65) | PTGS2PTGS1CA2CA7CNR1 | |
| SCHEMBL8689138 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1CA2CA7F10 | |
| SCHEMBL8689036 | 0.87 | PTGS2 (0.40) | PTGS2PTGS1CA2CA7CNR1 | |
| SCHEMBL6345546 | 0.80 | PTGS2 (0.83) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8691576 | 0.77 | CA2 (0.41) | PTGS2PTGS1CA2CA7CNR1 | |
| SCHEMBL8693265 | 0.75 | PTGS2 (0.52) | PTGS2PTGS1CA2CA7F10 | |
| SCHEMBL8693252 | 0.75 | PTGS2 (0.65) | PTGS2PTGS1CA2CA12CA1 | |
| SCHEMBL8422281 | 0.74 | PTGS1 (0.44) | PTGS2PTGS1CA2CA7CNR1 | |
| SCHEMBL8421921 | 0.74 | CA2 (0.44) | PTGS2PTGS1CA2CA7CNR1 | |
| SCHEMBL7059987 | 0.73 | PTGS2 (0.47) | PTGS2PTGS1CA2CA7F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |