Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.68 |
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633792 | 0.85 | USP2 (0.71) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL5432715 | 0.81 | MAPT (1.00) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL13271173 | 0.80 | USP2 (0.62) | ALDH1A1MAPTGAAKMT2AHTT | |
| SCHEMBL9233597 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL5527258 | 0.78 | MAPT (0.74) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL10125733 | 0.78 | MAPT (0.70) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL6450004 | 0.76 | ALDH1A1 (0.72) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL9095171 | 0.76 | GAA (0.59) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL20657355 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL5449567 | 0.75 | IDO1 (0.78) | ALDH1A1MAPTKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773459-A | ENZYME INHIBITORS OF KINASES AND ANTICARCINOGENIC AGENTS | SUGEN, INC. (US) | 1998-06-30 | — | — | US | claimed |
| US-5773459-A | ENZYME INHIBITORS OF KINASES AND ANTICARCINOGENIC AGENTS | SUGEN, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| WO-1996040673-A1 | NOVEL UREA- AND THIOUREA-TYPE COMPOUNDS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |