Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5700207 | 0.86 | KMT2A (0.55) | KMT2AMEN1KDM4CKDM4DAKR1C3 | |
| SCHEMBL7850570 | 0.80 | AKR1C3 (0.62) | KMT2AMEN1KDM4CKDM4DAKR1C3 | |
| SCHEMBL7824045 | 0.80 | AKR1C3 (0.62) | KMT2AMEN1KDM4CKDM4DAKR1C3 | |
| SCHEMBL30933589 | 0.79 | KDM4C (0.59) | KMT2AMEN1KDM4CKDM4DALDH1A1 | |
| SCHEMBL116912 | 0.79 | KDM4C (0.59) | KMT2AMEN1KDM4CKDM4DALDH1A1 | |
| SCHEMBL1643213 | 0.79 | ALDH1A1 (0.65) | KMT2AMEN1KDM4CKDM4DAKR1C3 | |
| SCHEMBL20385461 | 0.79 | KMT2A (0.55) | KMT2AMEN1KDM4CKDM4DAKR1C3 | |
| SCHEMBL28752271 | 0.78 | KMT2A (0.59) | KMT2AMEN1ALDH1A1VNN1MAPT | |
| SCHEMBL7230132 | 0.78 | KDM4D (0.41) | KMT2AMEN1KDM4CKDM4DALDH1A1 | |
| SCHEMBL22229509 | 0.78 | MGAM (0.54) | ALDH1A1VNN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817652-A | ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0683773-B1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | WELLCOME FOUND (GB) | 1997-09-17 | — | — | EP | disclosed |