Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343151 | 0.83 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL8689601 | 0.81 | PTGS2 (0.39) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8635859 | 0.81 | PTGS2 (0.41) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8693103 | 0.76 | KDM4E (0.31) | PTGS2PTGS1 | |
| SCHEMBL8689454 | 0.73 | PTGS2 (0.36) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL7928751 | 0.68 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8635925 | 0.68 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL6343089 | 0.67 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8525009 | 0.67 | PTGS2 (0.65) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8692227 | 0.67 | PTGS2 (0.44) | PTGS2PTGS1CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |