Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.62 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10830938 | 0.85 | TNF (0.58) | TNFCTNNB1KDM4EMAPTHSD17B10 | |
| SCHEMBL10487972 | 0.85 | KDM4E (0.62) | CTNNB1PARP1KDM4EHSD17B10RAB9A | |
| SCHEMBL7309296 | 0.84 | TDP1 (0.47) | TNFKDM4EHSD17B10GAALMNA | |
| SCHEMBL7300323 | 0.83 | HSD17B10 (0.48) | TNFKDM4EMAPTHSD17B10 | |
| SCHEMBL7300140 | 0.82 | FABP4 (0.68) | CTNNB1PARP1KDM4EHSD17B10 | |
| SCHEMBL7654811 | 0.81 | HSD17B10 (0.71) | TNFKDM4EMAPTHSD17B10LMNA | |
| SCHEMBL12938925 | 0.80 | TNF (0.64) | TNFCTNNB1KDM4ERAB9ACNR1 | |
| SCHEMBL6028786 | 0.80 | PGR (0.60) | PARP1KDM4EHSD17B10RAB9AGAA | |
| SCHEMBL1004476 | 0.79 | TNF (0.63) | TNFCTNNB1KDM4ECNR1CREBBP | |
| SCHEMBL1004093 | 0.79 | TNF (0.63) | TNFCTNNB1KDM4ECNR1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |