SCHEMBL869336

SCHEMBL869336

CN(C)c1cccc2c(S(=O)(=O)NCC(N)C(=O)O)cccc12

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.55
HDAC10 Q969S8 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
HDAC5 Q9UQL6 1/20 0.55
F2 P00734 2/20 0.54
PRSS1 P07477 2/20 0.54
PRSS2 P07478 2/20 0.54
PRSS3 P35030 2/20 0.54
EDNRA P25101 6/20 0.52
CA2 P00918 1/20 0.51
GBA1 P04062 2/20 0.51
PTGS2 P35354 1/20 0.49
EPHX2 P34913 1/20 0.48
HDAC1 Q13547 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13911551 1.00 HDAC4 (0.55) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL29936015 1.00 HDAC4 (0.55) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL29462219 1.00 HDAC4 (0.55) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL9163130 0.88 HDAC4 (0.58) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL14110615 0.88 HDAC4 (0.48) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL14110750 0.85 HDAC4 (0.55) HDAC4HDAC10HDAC6HDAC5F2
SCHEMBL13651429 0.85 HDAC4 (0.64) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL29358078 0.85 HDAC4 (0.64) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL597355 0.85 HDAC4 (0.64) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL18612351 0.82 EDNRA (0.59) HDAC4HDAC10HDAC6HDAC5F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116601297-A Modified helicase and application thereof 北京齐碳科技有限公司 2023-08-15 CN claimed
US-20230212535-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-07-06 US claimed
EP-4198125-A2 PIF1-LIKE HELICASE AND USE THEREOF Qitan Technology Ltd., Beijing (CN) 2023-06-21 EP claimed
EP-4063382-A9 PIF1-LIKE HELICASE AND APPLICATION THEREOF Qitan Technology Ltd., Beijing (CN) 2022-11-16 EP claimed
EP-4063382-A1 PIF1-LIKE HELICASE AND APPLICATION THEREOF Qitan Technology Ltd., Beijing (CN) 2022-09-28 EP claimed
US-20220290223-A1 PIF1-LIKE HELICASE AND USE THEREOF Qitan Technology Ltd. (CN) 2022-09-15 US claimed
CN-113930406-A Pif1-like helicase and application thereof 北京齐碳科技有限公司 2022-01-14 CN claimed
US-20210009971-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2021-01-14 US claimed
EP-3575410-A2 MODIFIED ENZYMES Oxford Nanopore Technologies Limited (GB) 2019-12-04 EP claimed
US-20180037874-A9 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2018-02-08 US claimed
US-20160257942-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2016-09-08 US claimed
EP-3058088-A2 MODIFIED ENZYMES Oxford Nanopore Technologies Limited (GB) 2016-08-24 EP claimed
CN-105899678-A Modified enzymes 牛津纳米孔技术公司 2016-08-24 CN claimed
US-20150191709-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2015-07-09 US claimed
US-9073973-B2 Dye conjugates of template-fixed peptidomimetics POLYPHOR LTD. (CH) 2015-07-07 US claimed
EP-2875128-A1 MODIFIED HELICASES Oxford Nanopore Technologies Limited (GB) 2015-05-27 EP claimed
WO-2015055981-A2 MODIFIED ENZYMES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2015-04-23 WO claimed
WO-2014013260-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2014-01-23 WO claimed
EP-1879911-B1 DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS POLYPHOR LTD (CH) 2011-08-17 EP claimed
US-20260028379-A1 MUTANT PORE OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-01-29 US disclosed
US-20250243472-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-07-31 US disclosed
US-12371458-B2 Mutant pore OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-07-29 US disclosed
US-12258591-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-03-25 US disclosed
US-12252717-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-03-18 US disclosed
US-20240417704-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-12-19 US disclosed
US-20240368568-A1 MODIFIED PRP43 HELICASE AND USE THEREOF QITAN TECHNOLOGY LTD., CHENGDU (CN) 2024-11-07 US disclosed
US-20240287485-A1 MODIFIED ENZYMES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-08-29 US disclosed
US-20240271122-A1 METHODS FOR CODON OPTIMIZATION AND USES THEREOF OXFORD FINANCE LLC, AS COLLATERAL AGENT 2024-08-15 US disclosed
US-20240254172-A1 MUTANT PORE OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-08-01 US disclosed
EP-4397970-A2 MUTANT PORE Oxford Nanopore Technologies PLC (GB) 2024-07-10 EP disclosed
CN-111534504-B Method of ligating one or more polynucleotide binding proteins to a target polynucleotide 牛津纳米孔科技公开有限公司 2024-06-21 CN disclosed
EP-4122949-B1 MUTANT PORE OXFORD NANOPORE TECH PLC (GB) 2024-06-05 EP disclosed
US-20240158735-A1 METHODS AND COMPOSITIONS USING AN ENGINEERED RELEASE FACTOR OXFORD FINANCE LLC, AS COLLATERAL AGENT 2024-05-16 US disclosed
WO-2024086738-A2 COMPOSITIONS AND METHODS OF USE FOR INTEINS GRO BIOSCIENCES INC. (US) 2024-04-25 WO disclosed
US-11965183-B2 Modified enzymes OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-04-23 US disclosed
US-11939359-B2 Mutant pore OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-03-26 US disclosed
US-20240026441-A1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE Oxford Nanopre Technologies PLC (GB) 2024-01-25 US disclosed
CN-116334030-B Modified CfM HL4 helicase and application thereof 深圳市梅丽纳米孔科技有限公司 2024-01-16 CN disclosed
EP-4299746-A1 MODIFIED PRP43 HELICASE AND USE THEREOF Qitan Technology Ltd., Chengdu (CN) 2024-01-03 EP disclosed
US-20230374567-A1 METHOD FOR MODIFYING A TEMPLATE DOUBLE STRANDED POLYNUCLEOTIDE OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-11-23 US disclosed
WO-2023198911-A2 NOVEL MODIFIED PROTEIN PORES AND ENZYMES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-10-19 WO disclosed
US-11725235-B2 Method for attaching one or more polynucleotide binding proteins to a target polynucleotide OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-08-15 US disclosed
US-20230227799-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-07-20 US disclosed
US-20230212535-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-07-06 US disclosed
CN-116334030-A Modified CfM HL4 helicase and application thereof 深圳市梅丽纳米孔科技有限公司 2023-06-27 CN disclosed
EP-4198125-A2 PIF1-LIKE HELICASE AND USE THEREOF Qitan Technology Ltd., Beijing (CN) 2023-06-21 EP disclosed
US-11649480-B2 Method for modifying a template double stranded polynucleotide OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2023-05-16 US disclosed
CN-115777019-A Modified Prp43 helicases and uses thereof 成都齐碳科技有限公司 2023-03-10 CN disclosed
EP-4122949-A1 MUTANT PORE Oxford Nanopore Technologies plc (GB) 2023-01-25 EP disclosed
EP-4108679-A1 MODIFIED ENZYMES Oxford Nanopore Technologies plc (GB) 2022-12-28 EP disclosed
US-11525125-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2022-12-13 US disclosed
US-11525126-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2022-12-13 US disclosed
EP-4063382-A9 PIF1-LIKE HELICASE AND APPLICATION THEREOF Qitan Technology Ltd., Beijing (CN) 2022-11-16 EP disclosed
EP-4063382-A1 PIF1-LIKE HELICASE AND APPLICATION THEREOF Qitan Technology Ltd., Beijing (CN) 2022-09-28 EP disclosed
US-20220290223-A1 PIF1-LIKE HELICASE AND USE THEREOF Qitan Technology Ltd. (CN) 2022-09-15 US disclosed
EP-3440098-B1 MUTANT PORE OXFORD NANOPORE TECH PLC (GB) 2022-07-27 EP disclosed
EP-3204406-B1 MODIFIED ENZYMES OXFORD NANOPORE TECH PLC (GB) 2022-07-06 EP disclosed
CN-114599666-A Pif1-like helicase and application thereof 北京齐碳科技有限公司 2022-06-07 CN disclosed
US-20220162568-A1 PORE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2022-05-26 US disclosed
US-20220135956-A1 MODIFIED ENZYMES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2022-05-05 US disclosed
EP-3097210-B2 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE OXFORD NANOPORE TECH LTD (GB) 2022-04-20 EP disclosed
CN-113930406-B Pif1-like helicase and application thereof 北京齐碳科技有限公司 2022-04-08 CN disclosed
US-20220064230-A1 MUTANT PORE OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2022-03-03 US disclosed
CN-113930406-A Pif1-like helicase and application thereof 北京齐碳科技有限公司 2022-01-14 CN disclosed
US-11180741-B2 Modified enzymes OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2021-11-23 US disclosed
US-20210123032-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2021-04-29 US disclosed
US-20210009971-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2021-01-14 US disclosed
EP-3741847-A1 MODIFIED HELICASES Oxford Nanopore Technologies Limited (GB) 2020-11-25 EP disclosed
EP-3464615-B1 METHOD OXFORD NANOPORE TECH LTD (GB) 2020-11-25 EP disclosed
US-10808231-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2020-10-20 US disclosed
US-10724018-B2 Modified helicases OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2020-07-28 US disclosed
US-20200087724-A1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2020-03-19 US disclosed
US-10385389-B2 Method for attaching one or more polynucleotide binding proteins to a target polynucleotide OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2019-08-20 US disclosed
US-20190202876-A1 MUTANT PORE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2019-07-04 US disclosed
US-20190194722-A1 METHOD OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2019-06-27 US disclosed
EP-3440098-A1 MUTANT PORE Oxford Nanopore Technologies Limited (GB) 2019-02-13 EP disclosed
CN-109219665-A Method 牛津纳米孔技术公司 2019-01-15 CN disclosed
CN-109071618-A MUTANT PORE 牛津纳米孔技术公司 2018-12-21 CN disclosed
EP-3097210-B1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE OXFORD NANOPORE TECH LTD (GB) 2018-11-14 EP disclosed
US-20180179500-A1 MODIFIED ENZYMES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2018-06-28 US disclosed
US-20180037874-A9 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2018-02-08 US disclosed
WO-2017174990-A1 MUTANT PORE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2017-10-12 WO disclosed
CN-107109380-A Modified enzymes 牛津纳米孔技术公司 2017-08-29 CN disclosed
EP-3204406-A2 MODIFIED ENZYMES Oxford Nanopore Technologies Limited (GB) 2017-08-16 EP disclosed
US-20170107569-A1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2017-04-20 US disclosed
EP-3097210-A1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE Oxford Nanopore Technologies Limited (GB) 2016-11-30 EP disclosed
US-20160257942-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LTD. (GB) 2016-09-08 US disclosed
CN-105647824-A In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris 斯克利普斯研究院 2016-06-08 CN disclosed
WO-2016055777-A2 MODIFIED ENZYMES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2016-04-14 WO disclosed
WO-2015183970-A1 THERAPEUTIC COMPOSITIONS INCLUDING FLAVONOID AND USES THEREOF STEALTH PEPTIDES INTERNATIONAL, INC. (MC) 2015-12-03 WO disclosed
WO-2015183963-A2 THERAPEUTIC COMPOSITIONS INCLUDING REDOX-ACTIVE PARABENZOQUINONES AND USES THEREOF STEALTH PEPTIDES INTERNATIONAL, INC. (MC) 2015-12-03 WO disclosed
CN-102307905-B Chemical reactivity alpha-non-natural amino acid is utilized to produce carrier-peptide conjugate THE SCRIPPS RESEARCH INSTITUTE (US) 2015-11-25 CN disclosed
US-9102932-B2 Orthogonal translation components for the in vivo incorporation of unnatural amino acids THE SCRIPPS RESEARCH INSTITUTE (US) 2015-08-11 US disclosed
WO-2015110813-A1 METHOD FOR ATTACHING ONE OR MORE POLYNUCLEOTIDE BINDING PROTEINS TO A TARGET POLYNUCLEOTIDE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2015-07-30 WO disclosed
US-20150191709-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2015-07-09 US disclosed
EP-2875128-A1 MODIFIED HELICASES Oxford Nanopore Technologies Limited (GB) 2015-05-27 EP disclosed
WO-2014013260-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2014-01-23 WO disclosed
US-20130244245-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids THE SCRIPPS RESEARCH INSTITUTE (US) 2013-09-19 US disclosed
US-8216804-B2 pairs of orthogonal-tRNAs (O-tRNAs) and orthogonal aminoacyl-tRNA synthetases (O RSs) that do not interact with the host cell translation machinery THE SCRIPPS RESEARCH INSTITUTE (US) 2012-07-10 US disclosed
US-8183037-B2 Expressing prokaryotic transfer RNA in yeast cells via vector transformation; disruuption of nonsense mediated messenger RNA decay THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2012-05-22 US disclosed
US-20120077224-A1 UNNATURAL AMINO ACID INCORPORATION IN EUKARYOTIC CELLS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2012-03-29 US disclosed
CN-102307905-A Production of carrier-peptide conjugates using chemically reactive unnatural amino acids SCRIPPS RESEARCH INST 2012-01-04 CN disclosed
EP-2383340-A2 Orthogonal translation components for the in vivo incorporation of unnatural amino acids The Scripps Research Institute (US) 2011-11-02 EP disclosed
EP-2380982-A1 Orthogonal translation components for the in vivo incorporation of unnatural amino acids The Scripps Research Institute (US) 2011-10-26 EP disclosed
CN-101939410-A In vivo unnatural amino acid expression in methylotrophic yeast Pichia pastoris SCRIPPS RESEARCH INST 2011-01-05 CN disclosed
WO-2010141851-A1 IMPROVING UNNATURAL AMINO ACID INCORPORATION IN EUKARYOTIC CELLS SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2010-12-09 WO disclosed
EP-2155890-A1 METHODS OF GENETICALLY ENCODING UNNATURAL AMINO ACIDS IN EUKARYOTIC CELLS USING ORTHOGONAL TRNA/SYNTHETASE PAIRS The Salk Institute for Biological Studies (US) 2010-02-24 EP disclosed
WO-2008127900-A1 METHODS OF GENETICALLY ENCODING UNNATURAL AMINO ACIDS IN EUKARYOTIC CELLS USING ORTHOGONAL TRNA/SYNTHETASE PAIRS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-10-23 WO disclosed
US-20080254540-A1 METHODS OF GENETICALLY ENCODING UNNATURAL AMINO ACIDS IN EUKARYOTIC CELLS USING ORTHOGONAL tRNA/SYNTHETASE PAIRS THE SALK INSTITUTE OFR BIOLOGICAL STUDIES 2008-10-16 US disclosed
US-20080233611-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids THE SCRIPPS RESEARCH INSTITUTE (US) 2008-09-25 US disclosed
US-20080233611-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids THE SCRIPPS RESEARCH INSTITUTE (US) 2008-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11525126-B2 Modified helicases DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885
US-20240417704-A1 MODIFIED HELICASES DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885
US-10808231-B2 Modified helicases DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885
US-20210123032-A1 MODIFIED HELICASES DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885
US-12252717-B2 Modified helicases DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885
US-20080233611-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids AARS1, NSUN3, OSGEP HDAC4 4356/4885HDAC10 3842/4885HDAC6 3240/4885
US-20260028379-A1 MUTANT PORE PTMS, NUP50, NUP205 HDAC4 4675/4885HDAC10 4041/4885HDAC6 4778/4885
US-20230227799-A1 MODIFIED HELICASES DDX21, DDX5, DDX17 HDAC4 2288/4885HDAC10 2655/4885HDAC6 1819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.