Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28465064 | 0.97 | SLC22A1 (0.50) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| SCHEMBL10002130 | 0.94 | SLC22A1 (0.47) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| SCHEMBL20175892 | 0.92 | SLC22A1 (0.50) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| SCHEMBL28465660 | 0.92 | SLC22A1 (0.50) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| Hydrochloric Acid SCHEMBL2581079 | 0.91 | KDM4E (0.50) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| SCHEMBL10002128 | 0.90 | DNM1 (0.50) | SLC22A1CYP3A4TSHRDNM1 | |
| Hydrochloric Acid SCHEMBL9755272 | 0.88 | SLC22A1 (0.62) | SLC22A1CYP3A4SLC5A7TSHRDNM1 | |
| Hydrochloric Acid SCHEMBL7155406 | 0.88 | SLC22A1 (0.62) | SLC22A1CYP3A4SLC5A7TSHRDNM1 | |
| SCHEMBL1686196 | 0.88 | TSHR (0.47) | SLC22A1KDM4EPMP22ATMCYP3A4 | |
| Water SCHEMBL25183773 | 0.86 | SLC22A1 (0.53) | SLC22A1TSHRNFKB1KCNA1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753214-A | SILYLATED PEPTIDES | SEIWA KASEI CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0699431-A1 | Base material for cosmetics and uses of the same | SEIWA KASEI CO., LTD. (JP) | 1996-03-06 | — | — | EP | disclosed |