Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111365 | 0.86 | CYP3A4 (0.53) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL11929770 | 0.84 | CYP3A4 (0.67) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL5321854 | 0.82 | CYP2A6 (0.49) | CYP3A4CYP2E1CYP2A6GRM5ICMT | |
| SCHEMBL7802849 | 0.81 | ALDH1A1 (0.56) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL20834430 | 0.81 | CYP3A4 (0.51) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL30797803 | 0.80 | CYP3A4 (0.57) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL16923147 | 0.80 | CYP3A4 (0.57) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL3507152 | 0.80 | CYP3A4 (0.57) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL20834215 | 0.80 | CYP3A4 (0.47) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 | |
| SCHEMBL17166601 | 0.80 | CYP3A4 (0.61) | CYP3A4CYP2E1CYP2A6GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316035-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180244671-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2018-08-30 | — | — | US | disclosed |
| WO-2017040450-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0703913-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029299-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316035-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | CYP3A4 225/4885CYP2E1 43/4885CYP2A6 655/4885 |
| US-20180244671-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | CYP3A4 225/4885CYP2E1 43/4885CYP2A6 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.