Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698719 | 0.90 | TSHR (0.50) | FOLH1TSHRCYP2C9HIF1AALDH1A1 | |
| SCHEMBL29062 | 0.89 | FOLH1 (0.66) | FOLH1TSHRKEAP1PTGER1PTGER4 | |
| SCHEMBL17938486 | 0.87 | TSHR (0.66) | FOLH1TSHRCYP2C9HIF1AALDH1A1 | |
| SCHEMBL69352 | 0.84 | TSHR (0.68) | FOLH1TSHRCYP2C9HIF1AALDH1A1 | |
| Phenyl Propionic Acid SCHEMBL7089831 | 0.83 | KEAP1 (0.63) | FOLH1TSHRKEAP1FFAR1CA1 | |
| SCHEMBL59198 | 0.82 | KEAP1 (0.65) | CYP2C9KEAP1PTGER1PTGER4PTGER3 | |
| SCHEMBL9566135 | 0.81 | CYP4F2 (0.53) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8696228 | 0.81 | TSHR (0.56) | FOLH1TSHRCYP2C9HIF1AALDH1A1 | |
| SCHEMBL27458277 | 0.79 | KEAP1 (0.63) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| Acetonitrile SCHEMBL28166333 | 0.79 | FOLH1 (0.54) | FOLH1TSHRKEAP1PTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827868-A | Prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1998-10-27 | — | — | US | disclosed |
| EP-0536713-A1 | Oxazole and imidazole derivatives as prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1993-04-14 | — | — | EP | disclosed |