Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | FDPS | P14324 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697127 | 0.88 | EPHX2 (0.64) | EPHX2FDPSALDH1A1TSHRBACE1 | |
| SCHEMBL18508968 | 0.88 | NFKB1 (0.67) | ALDH1A1TSHRAOX1BACE1MAPT | |
| SCHEMBL8699211 | 0.82 | TTR (0.49) | EPHX2FDPSALDH1A1BACE1MAPT | |
| SCHEMBL27890682 | 0.81 | BACE1 (0.77) | EPHX2FDPSALDH1A1BACE1MAPT | |
| SCHEMBL8685581 | 0.81 | JUN (0.77) | ALDH1A1BACE1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL27890681 | 0.81 | BACE1 (0.77) | EPHX2FDPSALDH1A1BACE1MAPT | |
| SCHEMBL8685579 | 0.81 | JUN (0.77) | ALDH1A1BACE1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL10956204 | 0.81 | BACE1 (0.55) | EPHX2FDPSALDH1A1BACE1MAPT | |
| SCHEMBL10956196 | 0.81 | BACE1 (0.55) | EPHX2FDPSALDH1A1BACE1MAPT | |
| SCHEMBL8694346 | 0.81 | EPHX2 (0.51) | EPHX2FDPSALDH1A1BACE1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756527-A | ANTICARCINOGENIC AGENTS | ONTOGEN CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0812830-A1 | Modulators of multi-drug resistances | ONTOGEN CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |