Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700111 | 0.88 | CYP3A4 (0.46) | ARCYP3A4CYP3A5CYP1A2CYP2C19 | |
| SCHEMBL8697052 | 0.84 | AR (0.41) | ARCYP3A4CYP3A5CYP1A2CYP2C19 | |
| SCHEMBL8700017 | 0.83 | CYP19A1 (0.42) | ARCYP3A4CYP3A5CYP19A1CYP11B2 | |
| SCHEMBL8698505 | 0.80 | CYP19A1 (0.38) | CYP3A4CYP3A5CYP19A1 | |
| SCHEMBL8700748 | 0.79 | CYP3A4 (0.36) | CYP3A4CYP3A5CYP1A2CYP2C19CYP19A1 | |
| SCHEMBL8696734 | 0.76 | CYP3A4 (0.53) | ARCYP3A4CYP3A5CYP1A2CYP2C19 | |
| SCHEMBL8697427 | 0.74 | CYP19A1 (0.42) | ARCYP3A4CYP3A5CYP2C19CYP19A1 | |
| SCHEMBL8700104 | 0.71 | CYP19A1 (0.45) | CYP3A4CYP1A2CYP2C19CYP19A1 | |
| SCHEMBL8698067 | 0.70 | CYP3A4 (0.47) | ARCYP3A4CYP3A5CYP19A1 | |
| SCHEMBL8697223 | 0.69 | CYP19A1 (0.56) | ARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |