SCHEMBL8700111

SCHEMBL8700111

N#Cc1ccc(C(F)(c2cncnc2)c2ccco2)c(F)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.46
CYP3A5 P20815 2/20 0.46
AR P10275 2/20 0.37
KIF11 P52732 1/20 0.36
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
CYP19A1 P11511 6/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
CYP11B2 P19099 4/20 0.32
CYP11B1 P15538 3/20 0.32
CYP17A1 P05093 1/20 0.32
HRH1 P35367 1/20 0.32
KCNH2 Q12809 1/20 0.32
GRM5 P41594 1/20 0.31
VNN1 O95497 1/20 0.31
EGLN2 Q96KS0 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8697496 0.88 AR (0.41) CYP3A4CYP3A5ARCYP19A1CYP1A2
SCHEMBL8696734 0.85 CYP3A4 (0.53) CYP3A4CYP3A5ARKIF11MEN1
SCHEMBL8697427 0.84 CYP19A1 (0.42) CYP3A4CYP3A5ARCYP19A1CYP2C19
SCHEMBL8700017 0.83 CYP19A1 (0.42) CYP3A4CYP3A5ARKIF11CYP19A1
SCHEMBL8697944 0.80 CYP3A4 (0.43) CYP3A4CYP3A5ARKIF11CYP19A1
SCHEMBL8700871 0.80 CYP3A4 (0.43) CYP3A4CYP3A5KIF11MAPTCYP19A1
SCHEMBL8697052 0.74 AR (0.41) CYP3A4CYP3A5ARCYP19A1CYP1A2
SCHEMBL8697223 0.72 CYP19A1 (0.56) ARCYP19A1
SCHEMBL8700104 0.71 CYP19A1 (0.45) CYP3A4GAACYP19A1CYP1A2CYP2C19
SCHEMBL8700748 0.70 CYP3A4 (0.36) CYP3A4CYP3A5KIF11CYP19A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO claimed
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO disclosed