Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697223 | 0.88 | CYP19A1 (0.56) | CYP19A1 | |
| SCHEMBL8702199 | 0.86 | CYP19A1 (0.45) | CYP19A1GRM5KDM4ESMN1; SMN2 | |
| SCHEMBL8696804 | 0.86 | CYP19A1 (0.66) | CYP19A1CYP3A4 | |
| SCHEMBL8700017 | 0.83 | CYP19A1 (0.42) | CYP19A1CYP3A4 | |
| SCHEMBL8697229 | 0.77 | CYP19A1 (0.55) | CYP19A1CYP3A4 | |
| SCHEMBL8697427 | 0.76 | CYP19A1 (0.42) | CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL8702192 | 0.74 | CYP19A1 (0.41) | CYP19A1ATMTSHRALDH1A1CYP3A4 | |
| SCHEMBL8700383 | 0.73 | CYP19A1 (0.49) | CYP19A1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8700111 | 0.71 | CYP3A4 (0.46) | CYP19A1CYP1A2CYP3A4CYP2C19GRM5 | |
| SCHEMBL8697496 | 0.71 | AR (0.41) | CYP19A1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |