Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 8/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697217 | 0.87 | PSMB8 (0.50) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8701281 | 0.85 | PSMB8 (0.64) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL31389040 | 0.79 | PSMB8 (1.00) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL799525 | 0.79 | PSMB8 (1.00) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8703017 | 0.79 | PSMB8 (0.46) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL13508871 | 0.78 | PSMB8 (0.61) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8701154 | 0.74 | PSMB8 (0.43) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL15887349 | 0.73 | PSMB8 (0.52) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8697415 | 0.73 | PSMB8 (0.64) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8701782 | 0.73 | PSMB8 (0.68) | PSMB8KEAP1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025913-A1 | NOVEL SUBSTITUTED 3H -BENZOXAZOLE-2-THIONES AND 3H -BENZOTHIAZOLE-2 THIONES DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1998-06-18 | — | — | WO | disclosed |